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If a patient is considered to need a sulfonamide medication to which they previously reacted, rechallenge and desensitisation may be appropriate for those with a mild maculopapular eruption

Further evaluation of metabolic models of the microbiota by examining 70 metabolic pathways from the KEGG database revealed a significant increase in the function of glutamate-cysteine ligase and GSH biosynthesis in the metformin-modulated microbiota (Fig