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Without targeted interventions to restore mitochondrial transport pathways and quench this raging oxidative fire, patients remain trapped in a devastating state of chronic cellular depletion and systemic hyper-reactivity, unable to break the cycle of fatigue and inflammation

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Clin Transl Sci 3(3):9097 Refaat MM, Lubitz SA, Makino S, Islam Z, Frangiskakis JM, Mehdi H, Gutmann R, Zhang ML, Bloom HL, MacRae CA, Dudley SC, Shalaby AA, Weiss R, McNamara DM, London B, Ellinor PT (2012) Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy

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