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GLP-1 and GIP/GLP-1 medications have boxed warnings regarding thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and carry risks of pancreatitis, gallbladder disease, and diabetic retinopathy progression

Conversely, necrotic sperm percentages increased at higher Nano-GTE levels, particularly at 200 g/mL (43.8 0.29%), suggesting potential cytotoxic effects of high Nano-GTE concentrations

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