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Tirzepatide Tirzepatide is a dual peptide, activating two hormone receptors, GLP-1(glucagon-like-peptide-1) and GIP (glucose-dependent insulin tropic polypeptide)

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It also interacts with MC3R, which is linked to metabolic regulation [6]

Third, given that the effect of GLP-1 RAs on DR may differ by sex, we performed subgroup analyses by stratifying the patients into two groups of men and women