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For most people, frequent urination caused by semaglutide is a short-term issue that resolves as the body adapts to the medication

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The study also reported improvements in cardiometabolic risk factors such as waist circumference, blood pressure, cholesterol levels, blood sugar markers, and inflammation

References Clayton AH, Althof SE, Kingsberg S, DeRogatis LR, Kroll R, Goldstein I, Kaminetsky J, Spana C, Lucas J, Jordan R, Portman DJ

In most cases, this is more relevant to pigmentation-related response and receptor sensitivity than to the neuroendocrine or sexual-arousal pathways more strongly linked to other melanocortin receptors in the brain