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10.3389/fnmol.2017.00367 Front Mol Neurosci

On the other, ISE directly downregulates the expression of v3 receptors in endothelial cells, blocking the binding of vWF to v3, thereby inhibiting the phosphorylation activation of the FAK/Src pathway

In addition, cathepsins are capable of degrading Bcl-2, thereby leading to exacerbated cellular apoptosis 5

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