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The structural unit of these transporters is composed of a transmembrane domain (TMD) that binds substrates and a nucleotide binding domain (NBD) for ATP hydrolysis

The proteomics technology developments applied was part of a project that has received funding from the European Unions Horizon 2020 research and innovation programme under grant agreements: MSmed-686547, EPIC-XS-823839, and ERC synergy grant 810057-HighResCells

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It is common for individuals afflicted with obesity to exhibit changes in the makeup of their circulating plasma fats, a condition known as dyslipidemia

The bottom line: Our findings suggest that GLP-1RA and SGLT2i (and especially SGLT2i with the lowest number needed to treat (NNT) for nearly all study outcomes) may be the preferred glucose-lowering agents for cardiovascular risk reduction in patients at moderate risk for CVD, building on and consistent with existing RCT evidence in the high-risk population. This report highlights potential preference for GLP-1 drugs as a first-line treatment for Type 2 diabetes related to its cardioprotective effect