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The accumulation of senescent cells, often referred to as the "old cell burden," is a concern because these cells can secrete a variety of harmful substances as part of the senescence-associated secretory phenotype (SASP)

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[Abstract] The levels of IL-1, TNF-, and IL-10 in the brain were investigated by ELISA in Dihexa-treated (1.44 mg/kg and 2.88 mg/kg) APP/PS1 mice

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