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Though, serum SOD activity and PCO level were altered in children with severe malaria in this study, corroborating some earlier reports, the association between severe malaria and PCO/SOD, and HCO 3 /glucose ratios has not been reported in previous literatures to the best of our knowledge and all these parameters exhibited relatively low sensitivity with relatively high specificity or vice versa ( Table 3 and Figure 1 )

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Why this matters for protocol design Three mechanistic features drive dosing decisions in research designs