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The first week of Wegovy treatment is primarily an introductory phase

Early morning or fasting nausea can occur because tirzepatide continuously activates GLP-1 and GIP receptors in your brain's nausea center, independent of food intake

PMID: 76 LeyDSahaS

Because most prove manageable

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body