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Pavlinov et al., 2020)

Recently, BRD4 was identified as a transcriptional repressor of autophagy and lysosomal biogenesis, independent of TFEB/TFE3/MITF-mediated mechanisms

Structural changes such as cardiomyopathy, cardiac hypertrophy, interstitial cardiac fibrosis, endothelial dysfunction, and contractile protein failure can result from elevated oxidative stress in cardiac tissue (Emran et al