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Hypertrophic adipocytes can promote the infiltration of macrophages into adipose tissue, thereby creating a local microenvironment characterized by a pro-inflammatory state, manifested by increased production of various cytokines, including tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and chemokines

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Physical activity increases blood flow to the working muscles, which can accelerate absorption of subcutaneously injected medication in ways that are unpredictable

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