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A GHRP (like Ipamorelin) also stimulates GH release but through a different receptor, and it amplifies the GHRH signal while also suppressing somatostatin, the bodys natural brake on GH

doi:10.1111/nure.12001

[PUBMED Abstract] Atkins MB, Kunkel L, Sznol M, et al.: High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update

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[2] This hyper-inflammatory state affects cardiac tissue leading to myocarditis, arteritis, and coronary aneurysm, resulting in reduced ejection fraction and cardiogenic shock