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Zinc repletion reduces promoter accessibility, thereby limiting IL-1 production under basal conditions, although it can still be induced by stimuli (danger signals) such as LPS [510]
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A double-blind randomized controlled trial demonstrated that adding memantine to conventional cinnarizine treatment significantly reduced tinnitus severity index scores compared to placebo, suggesting a beneficial effect (Pourayyoubi et al., 2025)
There was increased tight junction protein expression (e.g., zonula occludens-1 (ZO-1)) and transepithelial resistance, which significantly mitigates leaky gut syndrome and stabilizes cellular junctions [18]
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