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PI3K/AKT signaling in the APP/PS1 mouse model

3.2 Mitochondrial redox signaling as a means of inter-organellar communication If ERmitochondria calcium coupling represents an early trigger of injury, redox signaling is one of the main mechanisms by which that injury is propagated to the rest of the organelle network

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Selective CBS inhibitors with minimal off-target effects on other PLP-dependent enzymes, CPERS-specific CARS modulators, and highly selective ETHE1 and TST inhibitors have not yet been reported