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However, in the striatum, which is located in the subcortical forebrain, insulin influences dopamine reuptake and release, with IR opposing these effects, impacting neuronal excitatory projections [90]

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Conclusion: Berberine can maintain the identity and normal function of islet cell, and its mechanism is related to the activation of GLP-1/GLP-1R/PKA signal pathway in intestinal L cell and islet cell

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