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Retatrutide is one of the newest medications in the weight and metabolic space, and it is still working its way through late-stage trials and early use

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The inhibition, which shows dose dependency, is exerted via interactions with receptors in the brain that are accessible via leaks in the blood-brain barrier of the circumventricular organs, mainly the postrema area, the subfornical organ and the median eminence [10, 11]

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By activating both pathways simultaneously, tirzepatide produces significant improvements in glycaemic control and substantial weight reduction