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In the VITACOG trial, high-dose B vitamins in older adults with mild cognitive impairment and elevated homocysteine reduced atrophy in the gray matter regions most vulnerable to Alzheimers disease, with the placebo group losing about 3.7 percent and the treatment group about 0.5 percent over two years

The study used specific concentrations in topical applications: PGD2 at 10 micrograms, PTD-DBM at 10 millimolar, DHT at 100 micromolar, and KY19382 at 2 millimolar