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For many patients, yes

Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons

Raw images were analysed in Fiji using the Coloc 2 plugin to determine SNAP/FLAG-hGLP-1R co-localisation with D4H*-mCherry

Pan, W., Hsuchou, H

Meanwhile, the BODIPY-cholesterol efflux assay indicated that EX-4 treatment alone or cholesterol co-treatment dramatically increased cholesterol efflux from INS-1 cells compared with the single cholesterol stimulation group or the control group (Figure 1J)