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This peptide is the active ingredient in the topical copper peptides that have been sold as cosmetic agents on the dermatology shelf since the late 1980s, with the caveat being that topical GHK-Cu needs to penetrate the stratum corneum layer of skin before getting to the dermis, which houses the receptors for the peptide

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This enzyme is expressed in different cells in several mammalian species, it has been distributed in numerous organs/tissues such as liver, lung, intestinal epithelium, placenta, kidney, renal proximal tubules and neurons, as well as in body fluids such as urine, plasma and cerebrospinal fluid [43,44]

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The alarmingly high prevalence of obesity necessitates the need for more effective anti-obesity medications