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PI3K/Akt/mTOR + MAPK/ERK Activates both the metabolic (PI3K/Akt/mTOR - protein synthesis, glucose uptake) and proliferative (MAPK/ERK) IGF-1 signalling cascades

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Indeed, G6PD, by virtue of its importance in fundamental redox homeostasis and anabolic metabolism, plays a multifaceted, ubiquitous role in human physiology, including within immune responses

39 The interaction between melatonin and antioxidant enzymes ultimately leads to reduced oxidative stress and helps minimize the contribution of free radical damage to the progression of NCDs