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To summarize, it appears that HB can increase the UCP protein expression in the brain, while C10 may potentially activate UCPs to increase the proton leak (Figure 2)

This is where the "clash" happens

5 These guidelines align with the American Diabetes Association (ADA) standards of care which also provide strong recommendations based on robust clinical trial data supporting the cardiovascular benefits of GLP-1 RAs, particularly in patients with established cardiovascular disease and chronic kidney disease (CKD)

Infine, non raccomandato per le donne in gravidanza o in allattamento senza il consenso del medico