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The objective of the study is to demonstrate superiority to placebo in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score reduction and in body weight reduction from baseline to week 68 in people with a BMI 27.0 kg/m and who met clinical and radiological American College of Rheumatology Criteria for knee osteoarthritis

Stem Cell Rev and Rep 21 , 18221834 (2025)

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Similar to SYGL-1 and LST-1, Ascl2 and LgR5 expression is limited to stem cells [50, 51], and ectopic expression promotes hyperplasia [52]