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This means: No human PK reference data No human bioavailability data No human metabolism or clearance data Rodent-to-human PK extrapolation is therefore speculative This is a major context for research framing

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Standard protocols recommend 2-2.5 mg administered subcutaneously twice weekly for acute conditions, or 750 mcg twice weekly for maintenance therapy

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Apart from vegans and people with gastrointestinal conditions, infants and children from B12-deficient mothers and the elderly are at particular risk of B12 deficiency