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4.5 Intranasal administration Drugs delivered to the olfactory region via IN can reach the olfactory bulb and other CNS regions within minutes via intracellular and extracellular pathways along the olfactory nerves or diffusion (especially for lipophilic small molecules), allowing for a higher concentration of the therapeutic agents in the brain compared to the bloodstream

The GutBrain Axis and Appetite Regulation The gastrointestinal tract communicates directly with the brain through a network known as the gutbrain axis

Fructose contributes to the Warburg effect for cancer growth

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The model demonstrated that exposure ratios between the subgroups were similar or slightly smaller on day 10 compared with steady state (details not shown), thereby confirming that the primary conclusions regarding exposure ratios across the 10-day trials are applicable at steady state