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Coffee enemas involve introducing brewed coffee into the colon via the rectum, a practice popularised by alternative medicine practitioners who claim it 'detoxifies' the liver and stimulates bile flow

5.7 Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, when used in combination with insulin

However, Ipamorelin appeared to cause a significant acceleration of gastric emptying compared to the vehicle control group

This is especially relevant if youre running or hiking in the outdoors on a hot day