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Overall, these data show that dopamine clearly influences the development of hypertension and likely other kidney diseases and suggest that continued investigation of dopaminergic agents is a promising direction for the treatment of hypertension

Supporting this conclusion, depletion of the gut microbiota decreases dopamine synthesis or increases dopamine turnover in the brain and intestine (Asano et al., 2012

Naunyn Schmiedebergs Arch Pharmacol 379:385388

Dosage ranges from 0.5 mg per day for general wellness up to 2 to 3 mg per day for wound healing

d ) Bar plot showing the total number of TH+ positive cells that do not colocalize with EBF3 ( Trkb Penk-WT , 66.5 5.3 vs Trkb Penk-KO , 71 5.0