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The FDA has approved Foundayo (orforglipron), making it the second oral GLP-1 medication specifically approved for weight loss

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Glucagon like peptide-1 (GLP-1) is a key insulinotropic hormone of intestinal origin released postprandially that endogenously stimulates insulin secretion from pancreatic cells and suppresses glucagon secretion to regulate glucose homeostasis and energy balance

Ormazabal V, Nair S, Elfeky O et al (2018) Association between insulin resistance and the development of cardiovascular disease

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