Losing too much muscle during rapid weight loss can slow down metabolism, leading the body to burn fewer calories at rest
Furthermore, the induction and upregulation of antioxidant enzymes, specifically superoxide dismutase and glutathione peroxidase, coupled with the downregulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and malondialdehyde levels, may represent a mechanism through which GLP-1 receptor agonists exert their antioxidative effects [20]
This suggests that metformin treatment alters energy metabolism in rectal adenocarcinoma tissue, but not in non-cancer rectal tissue biopsies, supporting its potential utility as a radiosensitiser in rectal cancer
But on November 10, 2025, the FDA just did something remarkable: they admitted tho
Measurable weight changes (13% of baseline) typically manifest within 48 weeks