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Wright and Harding are co-founders of M3 Biotechnology, Inc

Insulin resistance occurs when cells stop responding effectively to insulin signals, forcing the pancreas to produce more insulin to maintain blood sugar control

Individuals with diabetes characterized by HbA1c 6.5%, or a history of surgical or device-based obesity treatment, were excluded

10.1016/S0006-291X(84)80190-4 148 GodoyL

Retatrutide (LY3437943) is a synthetic 39-amino acid triple-hormone receptor agonist targeting GIP, GLP-1, and glucagon receptors simultaneously, commonly referenced in scientific literature for metabolic research, obesity mechanism studies, hepatic steatosis models, and energy expenditure pathway investigations in laboratory and preclinical environments