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Anti-apoptotic effects of GLP-1RAs In both diabetic and non-diabetic rodent models of cerebral ischemia, exenatide, lixisenatide, semaglutide, and liraglutide increased the expression of the anti-apoptotic factor B-cell lymphoma 2 (Bcl-2) and decreased the expression of the pro-apoptotic factor Bcl-2-associated X protein (Bax), consequently leading to a reduced Bax/Bcl-2 ratio and reduced apoptosis, possibly through ROS reduction and activation of the PI3K/Akt and MAPK pathways [73, 86, 87, 92, 93]

doi: 10.1016/S2468-1253(24)00246-2 146 ZhangZChenMXuYWangZLiuZHeCet al

GLP-1 medications can be given anywhere from once or twice daily to once weekly, depending on the specific drug

Other important side effects include hypoglycaemia (particularly when used in combination with insulin or sulphonylureas), injection site reactions, fatigue, and dizziness