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It is worth mentioning that SGLT-2 inhibitor use is restricted in patients with renal failure, in which case GLP-1 receptor agonists are considered (down to an eGFR of 15 ml/ml) [68]

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Benefits Beyond Weight Loss While shedding excess weight is often the first goal, GLP-1 medications offer a broader spectrum of benefits when combined with comprehensive care: Better metabolic control: Improved insulin sensitivity can reduce risk factors for diabetes and cardiovascular disease

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