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Psychiatry 74 , 11881199 (2003)

As the cycle progresses to the late follicular phase, GnRH pulse frequency accelerates to 60-minute intervals, facilitating a shift toward LH dominance that culminates in the preovulatory LH surge, reflecting the transition in hormonal predominance from FSH to LH, as is required for successful ovulatory cycles ( In PCOS, however, diminished sensitivity of GnRH neurons to steroid hormone negative feedback results in increased GnRH pulse frequency, driving preferential pituitary LH hypersecretion and concomitant FSH suppression, resulting in an elevated LH/FSH ratio ( Anti-Mllerian hormone (AMH) and FSH are pivotal biomarkers in PCOS, serving as indicators of oocyte competence and ovarian reserve ( 6.2 Regulation of granulosa cell proliferation and apoptosis Resveratrol demonstrates multifaceted therapeutic potential in ameliorating PCOS by targeting granulosa cell (GC) dysfunction and mitochondrial anomalies

Intramuscular injections are often near the injury for localized effect

The critical variable is cumulative thermal load