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Aims to reduce health-related risks linked to being overweight or obese

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Stages 1-3 CKD: standard dosing protocol typically appropriate, with more frequent kidney function monitoring Stage 4 CKD: standard starting dose with very close monitoring, particularly for dehydration, AKI, and medication interactions Stage 5 CKD: generally avoided unless under specialist nephrologist care The standard dose-escalation schedule increases the dose every 4 weeks