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Aminian A, Zajichek A, Arterburn DE, Wolski KE, Brethauer SA, Schauer PR, et al

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73,85 Target Modification The influence of GSH on redox homeostasis can impact mutation rates and post-translational modifications of antibiotic targets

In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29