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Liraglutide as add-on to sodium-glucose co-transporter-2 inhibitors in patients with inadequately controlled type 2 diabetes: LIRA-ADD2SGLT2i, a 26-week, randomized, double-blind, placebo-controlled trial

Phase 2 Published 2023 The New England Journal of Medicine The most-cited medical journal in the world Jastreboff et al., 2023 338 adults with obesity, randomized to placebo or one of four Retatrutide doses (1, 4, 8, 12 mg weekly)

3.2 Interference with lipid metabolism Changes in gut microbiota among PCOS patients significantly influence lipid metabolism through various mechanisms (50)

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According to current guidance: GLP-1 medications are FDA-approved only for adolescents aged 12 and above with severe obesity (defined as a BMI of 120% or more of the 95th percentile)