About 82% of people taking tirzepatide achieved at least 5% weight loss after one year, compared to 67% of those on semaglutide
A Nuanced Take GLP-1 medications can be life-changing and medically appropriate for many, especially those with diabetes
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A: GLP-1 (glucagon-like peptide-1) weight loss medications are injectable drugs that mimic a natural hormone in your gut responsible for regulating hunger, slowing digestion, and improving blood sugar control
Mechanistically, an in vitro study found that exendin-4 inhibited the secretion of IL-1 and TNF- from mouse colonic smooth muscle cells (CSMCs) via the pathway mediated by cAMP and NF-B, thereby exerting anti-inflammatory effects [218]