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Other factors include: INFECTIONS AND MOLECULAR MIMICRY A persistent theory on the etiology of autoimmune diseases is that exposure to a particular peptide epitope in an environmental antigen might lead to immune reactivity to an amino acid sequence identical to that present in a human antigen such as the TSH-R, thyroperoxidase (TPO), or thyroglobulin (Tg)

Additionally, losing body fat can enhance body composition by increasing lean muscle mass and improving overall body shape and definition

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When someone stops taking them, those signals can come back