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Through upregulating TP53 activity, GNA lowered the expression levels of GPX4 and SLC7A11, leading to dysregulation of cellular lipid peroxides, and eventually ferroptosis in transforming growth factor-1 (TGF-1)-induced EMT melanoma models (Wang et al., 2020)

[Google Scholar] Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P

doi: 10.1002/hep.21131 79 ShanS.ShenZ.SongF

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GH-Axis Side Effects Are Biologically Plausible Because CJC-1295 is designed to increase GH-axis signaling, GH-related effects such as fluid retention, edema, joint discomfort, paresthesias, and carpal-tunnel-like symptoms are relevant safety endpoints, even when not proven specifically for every form of CJC-1295