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It's whether the neurobiological conditions for synaptogenesis are met

The 8mg dose achieved 21.1% weight loss (matching Zepbounds efficacy) with lower side effects: 24% nausea versus 28% at 12mg, 8.4% discontinuation versus 11.2%

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This neuronal gene activation correlates with observed anti-pain, anti-anxiety, and cognitive enhancement effects in animal studies at doses as low as 0.5 g/kg body weight