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Melanocytes can also function as neuroendocrine cells by producing acetylcholine, catecholamines, and POMC-derived peptides, which have the capacity to mediate local immunoinflammatory and antimicrobial responses and to modulate the biological behaviour of oral tissues [4]

Group 1 received the OCP (estradiol/gestodene) tablet orally alone, while Group 2 received the same tablet in combination with myo-inositol

As with any cosmetic procedure, it is also not for pregnant or breastfeeding women or anyone with an active skin infection in the area

Dull skin concerns Uneven skin tone users People seeking daily brightening care All skin types

These additionally internalized receptors are for the most part dimerized with MC3R (Schellekens et al., 2013), suggesting that dimerization with MC3R may not only lead to reduced efficiency of GHSR1a signaling, but also to reduced surface expression of the receptor