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Moreover, the drug-refractory epilepsy patients accounted for about 1/3rd of the total epilepsy patients who showed no apparent response to the commonly used AEDs (Mosh et al., 2015)

Extracellular matrix structure[J]

Sleep apnea causes oxygen levels to drop by 3-4% during breathing interruptions, starving brain tissue and triggering vascular headaches that peak within 30 minutes of waking

Molecular Brain 2010

Animal studies show that gadolinium can cause low glutathione levels.[ref] Mercury is another heavy metal that utilizes glutathione in the detoxification pathways.[ref] Arsenic exposure causes increased glutathione usage