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Measurement of binding of CS agents on MRP1 The impact of ligand binding on intrinsic fluorescence was monitored using a Xenius XC spectrofluorometer (SAFAS) in quartz cuvettes containing 200 l of MRP1 at 0.5 M in 150 mM KCl, 50 mM Tris pH 8.0, 2 mM MgCl 2 , 2 mM DTT, and 0.06% digitonin

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Coffin et al., in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., 2008

Inhibitory phosphorylation site for rho-associated kinase on smooth muscle myosin phosphatase