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Indeed, the placebo fibrosis-improvement rate of 22% is a useful reminder of how noisy single biopsy-based fibrosis staging can be over less than a year, which is one reason regulators want multi-year outcome data before treating a fibrosis claim as established

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3.4 Immune modulatory mechanisms of probiotic in SLE Early on in the inflammatory process, changes in innate immune cells within the intestines have been observed, including mast cells, dendritic cells, neutrophils, and macrophages