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Extended titration, where you stay at a lower dose for longer before increasing, is the evidence-based approach to managing GI side effects and may solve your problem without any experimental modifications

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The problem is that the trials don't tell you what 2.5 mg does over 72 weeks

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This underscores the importance of considering both ECM protein composition and mechanical properties in future studies, as the interplay between these factors significantly influences how cells interpret and respond to mechanical signals, thereby affecting cellular function and differentiation pathways