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while 7 of the 12 patients reported subjective pain relief exceeding six months, the complete absence of a placebo control group or standardized pain-scale methodology severely limits the scientific validity and reproducibility of the findings

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The transcription regulator, forkhead box class O isoforms 4 (FOXO4), maintains the viability of senescent cells by localizing adjacent to p53-pS15 to prevent the nuclear exclusion of active p53-pS15 to mediate apoptosis 11

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& Kruzel, M