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Based on these results, we hypothesized that GLP-1R in the TNC mediates microglial activation via the PI3K/Akt pathway and suppresses the central sensitization of CM

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Importantly, weight loss with GLP-1 RAs has accompanied improvements in metabolic parameters and obesity-related comorbidities (e.g., glycemic control, lipid profiles, liver enzymes) in adolescents, mirroring findings in adults (see e.g., NASPGHAN and Endocrine guidelines)

How Semaglutide is Administered Semaglutide is available in two main forms: Injectable Form: The injectable form of semaglutide is administered once a week

Patients who have repeated weight measurements might be the extremes of weight change.