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Because B12 is water-soluble, excess amounts are naturally excreted by the body, making toxicity extremely rare

Furthermore, an imbalance in iron homeostasis has been linked to respiratory diseases, with iron overload and mitochondrial dysfunction playing significant roles in pulmonary dysfunction and pulmonary fibrosis [47]

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Complexation using other ligands can also be explored but GHK is commonly used in cosmetics with properties such as the stimulation of collagen synthesis, chemotaxis, anti-stinging effects and others 47