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In preclinical models, BPC-157 has demonstrated the ability to accelerate healing of the intestinal lining, support mucosal tissue repair, and promote angiogenesis, the formation of new blood vessels that supply healing tissue

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Other GU effects reported in 0.1% to 1% of patients during clinical trials of topiramate as monotherapy or adjunct therapy for epilepsy included urinary retention, renal pain, albuminuria, polyuria, and oliguria

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This remains unaddressed by long-term monitoring, and most practitioners recommend that individuals with a history of cancer or active malignancy avoid BPC-157