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Enhancing GLP-1 signaling in older individuals could mitigate chronic inflammation, improve metabolic equilibrium, and support neuroprotection, collectively contributing to extended healthspan and potentially lifespan

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Although whether alpha-cell GLP-1 production and maturity state directly relate to alpha-cell proliferative state has yet to be established, these studies identify a range of alpha-cell maturity and proliferative capacity within islets and allude to the possibility that alpha-cell GLP-1 production may be inherently involved in this heterogeneity

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